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Droperidol, when used for sedation during ERCP, may prolong the QT interval
Panot Yimcharoen1, Evan L Fogel, Richard J Kovacs
1Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, University Medical Center, 550 N. University Blvd., Indianapolis, IN 46202, USA.
Gastrointestinal Endoscopy
|May 31, 2006
Summary
Droperidol may prolong the corrected QT interval (QTcB) during endoscopic retrograde cholangiopancreatography (ERCP) sedation. However, this study found no serious cardiac arrhythmias, suggesting droperidol is likely safe when patients are monitored post-procedure.
Area of Science:
- Cardiology
- Gastroenterology
- Pharmacology
Background:
- Droperidol is an effective sedative for endoscopic procedures.
- FDA warnings in 2001 raised concerns about droperidol's cardiac safety.
- The study addresses safety concerns regarding droperidol's use in clinical practice.
Purpose of the Study:
- To evaluate droperidol's effect on the corrected QT interval (QTcB) in ERCP patients.
- To assess the frequency of cardiac arrhythmias associated with droperidol administration.
Main Methods:
- Retrospective review of medical records for ERCP patients who received droperidol.
- ECG monitoring before and 1-3 hours after the procedure for patients receiving droperidol.
- Analysis of QTcB intervals and cardiac arrhythmia occurrences.
Main Results:
- 3113 patients received droperidol during ERCP.
- QTcB prolongation occurred in 7.48% of patients.
- No serious dysrhythmias were observed, despite some QTcB prolongation.
Conclusions:
- Droperidol can cause QTcB prolongation at standard doses.
- Clinically significant cardiac events appear rare with droperidol.
- Pre-procedure ECG and post-procedure monitoring are adequate for droperidol use.
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