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Updated: Aug 8, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
[Proinflammatory and proallergic cytokines in the pathology of developmental age]
Elzbieta Maciorkowska1, Maciej Kaczmarski
1Zakład Pielegniarstwa Pediatrycznego, Akademia Medyczna, ul. Waszyngtona 15, 15-745 Białystok, Poland. emaciorkowska@o2.pl
Abstract:
Cytokines are a heterogenic group of proteins with high biological activity, synthesized and secreted by given cells or group of cells taking part in growth or their multiplication, and also in the course of immune and inflammatory reactions. They are responsible for morphological and functional conditions of numerous organs and systems, and for local and general immune responses with accompanying clinical symptoms. The role of cytokines as mediators of inflammatory and allergic reactions seems to be particularly important. Cytokine activity manifested in the final biological effect, is regulated by many substances present in the environment surrounding the effector cell i.e. specific inhibitors, humoral and growth factors. The effect of final cytokine activity in the organism does not take place in the isolated environment, but in the system of interactions and correlations known as the cytokine network.
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