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[Voriconazole photosensitivity: 7 cases].

N Auffret1, F Janssen, P Chevalier

  • 1Unité fonctionnelle de Dermatologie, Hôpital Européen Georges Pompidou, Paris.

Annales De Dermatologie Et De Venereologie
|May 31, 2006
PubMed
Summary
This summary is machine-generated.

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Voriconazole, an antifungal medication, can cause photosensitivity, a rare side effect. Patients taking voriconazole should be advised about sun protection to prevent adverse skin reactions.

Area of Science:

  • Mycology
  • Dermatology
  • Pharmacology

Context:

  • Voriconazole is a potent triazole antifungal used for invasive fungal infections.
  • Immunocompromised patients, particularly transplant recipients, are at high risk for severe fungal infections.
  • Voriconazole is indicated for refractory Candida infections and invasive aspergillosis.

Purpose:

  • To report 7 cases of photosensitivity reactions in patients treated with voriconazole.
  • To highlight a rare but significant adverse effect of voriconazole therapy.

Summary:

  • Seven immunocompromised patients (5 women, 2 men; mean age 38) developed photosensitivity within 5 to 14 months of starting voriconazole.
  • The patients had undergone organ transplantation or were on long-term steroids and were treated for pulmonary aspergillosis or Scedosporium infection.

Related Experiment Videos

  • Photosensitivity resolved rapidly upon discontinuation of voriconazole, with lesions appearing after sun exposure.

    • Impact:

    • Voriconazole-induced photosensitivity is a rare but important adverse effect to recognize.
    • Clinicians should counsel patients on the risk of photosensitivity and recommend sun protection.
    • Awareness of this side effect is crucial for managing patients on voriconazole, especially during increased sun exposure.