Asymptotic theory of an infectious disease model
Alan M Whitman1, Hashem Ashrafiuon
1Department of Mechanical Engineering, Villanova University, 800 W. Lancaster Ave., Villanova, PA 19085, USA. alan.whitman@villanova.edu
Abstract:
In this paper, we present asymptotic theory as a viable alternative solution method for infectious disease models. We consider a particular model of a pathogen attacking a host whose immune system responds defensively, that has been studied previously [Mohtashemi and Levins in J. Math. Biol. 43: 446-470 (2001)]. On rendering this model dimensionless, we can reduce the number of parameters to two and note that one of them has a large value that suggests an asymptotic analysis. On doing this analysis, we obtain a satisfying qualitative description of the dynamic evolution of each population, together with simple analytic expressions for their main features, from which we can compute accurate quantitative values.
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