Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanced desorption ionization using oxidizing electrosprays.

Marcela Nefliu1, R Graham Cooks2, Colin Moore3

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, 47907-2084, West Lafayette, IN.

Journal of the American Society for Mass Spectrometry
|June 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry.

Chemical communications (Cambridge, England)·2026
Same author

Accelerated and Green Synthesis of <i>N,S</i>- and <i>N,O</i>-Heterocycles in Microdroplets.

Journal of the American Chemical Society·2026
Same author

Catalyst-Free C-N Coupling under Ambient Conditions via High-Throughput Microdroplet Reactions.

The Journal of organic chemistry·2025
Same author

Rapid Selective Detection of Phosphatidylethanols by Neutral Loss Scans in Tandem Mass Spectrometry to Evaluate Alcohol Consumption.

Analytical chemistry·2025
Same author

Ambient ionization mass spectrometry in brain cancer diagnosis.

Journal of mass spectrometry and advances in the clinical lab·2025
Same author

Chemoselective cyclodesulfurization <i>vs.</i> dehydration enabled by aqueous microdroplet chemistry.

Chemical science·2025
Same journal

Characterization of Alkane Oxidation Products in a Corona-Discharge Reactor Using Ammonia-Doped Ion Mobility-Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2026
Same journal

Integration of a Modified Synchrotron Radiation Photoionization Time-of-Flight Mass Spectrometer with a Residual Gas Analyzer for Complementary Detection of Catalytic Products with Different Ionization Energies.

Journal of the American Society for Mass Spectrometry·2026
Same journal

Screen for Tissue-Specific Markers of Drug-Induced Phospholipidosis Using Mass Spectrometry Imaging.

Journal of the American Society for Mass Spectrometry·2026
Same journal

Molecular Framework Modification in Mass Spectrometry: Atom Exchange, Insertion, and Deletion.

Journal of the American Society for Mass Spectrometry·2026
Same journal

Interlaboratory Comparison of Orbitrap Analyzers in OrbiSIMS: Noise Parameters, Intensity Scaling, and Detection Limits.

Journal of the American Society for Mass Spectrometry·2026
Same journal

Isotope-Coded Derivatization Enables Accurate LC-MS/MS Quantification of Urinary THC-COOH without Isotope-Labeled Cannabinoid Standards.

Journal of the American Society for Mass Spectrometry·2026
See all related articles

Reactive desorption electrospray ionization (DESI) significantly enhances signal detection for copper complexes. Adding oxidants to the spray solvent boosts signal intensity by two orders of magnitude, improving analytical sensitivity.

Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Materials Science

Background:

  • Copper complexes, such as copper(II) dibutyl dithiocarbamate (Cu(II)(bu2dtc)2), are relevant in specialized polymers.
  • Desorption electrospray ionization (DESI) is a surface-based ambient ionization technique for mass spectrometry.
  • Oxidation of metal ions can alter their detection and characterization.

Purpose of the Study:

  • To investigate the use of reactive DESI for enhanced signal detection of Cu(II)(bu2dtc)2.
  • To explore the role of oxidants in the DESI spray solvent for signal enhancement.
  • To characterize the oxidized copper species and their fragmentation patterns.

Main Methods:

  • Utilized reactive desorption electrospray ionization (DESI) with varying oxidants in the spray solvent.

Related Experiment Videos

  • Analyzed copper(II) dibutyl dithiocarbamate (Cu(II)(bu2dtc)2) within a specialized polymer matrix.
  • Employed collision-induced dissociation (CID) and MS3 for product ion analysis.
  • Correlated oxidant reduction potential with signal intensity and signal-to-noise ratio.

    • Main Results:

    • Achieved a signal enhancement of two orders of magnitude for Cu(II)(bu2dtc)2 using reactive DESI with added oxidants (e.g., iodine).
    • Observed oxidation of Cu(II) to Cu(III) during the DESI process.
    • Demonstrated a correlation between the oxidant's standard reduction potential and the observed signal enhancement.
    • Identified major product ions in the CID spectrum of Cu(III)(bu2dtc)2]+ using isotopic distributions and MS3 data.

    Conclusions:

    • Reactive DESI with appropriate oxidants offers a powerful method for significantly enhancing the detection of copper complexes.
    • The observed oxidation enhancement in DESI is greater than that achievable in homogeneous solutions.
    • This technique provides a sensitive approach for analyzing metal-organic compounds in complex matrices.