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Linkage disequilibrium between the HLA-DQA2 alleles and the HLA/DR/DQ complex
S Ratanachaiyavong1, J L Bidwell, E A Bidwell
1Department of Medicine, King's College School of Medicine and Dentistry, London, United Kingdom.
Human Immunology
|February 1, 1991
Abstract:
A statistically significant association was observed between alleles of the HLA-DQA2 and of the DR/DQ complex in a DNA-restriction fragment length polymorphism study of 219 members from 21 multiplex families of patients with hyperthyroid Graves' disease and 773 unrelated individuals selected for homozygosity of the HLA-DQA2 alleles. This data provides evidence for linkage disequilibrium rather than for a hot spot of recombination within the HLA-DQ subregion.