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Synthesis of pterocellin A
Meaghan M O'Malley1, Fehmi Damkaci, T Ross Kelly
1E. F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
Abstract:
The first total synthesis of pterocellin A (1) was achieved in 10 linear steps from commercially available kojic acid (6) and 2-bromo-3-pyridinol (11) in a convergent sequence. The key constructive steps are a directed lithiation to couple two pyridines and an intramolecular nucleophilic aromatic substitution to form 1. [structure: see text]
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