Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

Synthesis of cribrostatin 6.

Michael D Markey1, T Ross Kelly

  • 1Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

The Journal of Organic Chemistry
|September 2, 2008
PubMed
Summary

The synthesis of cribrostatin 6 was achieved using key steps including regioselective bromination, biaryl coupling, and intramolecular cyclization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Rationally Designed Prototype of a Molecular Motor.

Journal of the American Chemical Society·2018
Same author

Nanotechnology: A molecular assembler.

Nature·2017
Same author

Synthesis of santiagonamine.

Organic letters·2007
Same author

Progress toward a rationally designed, chemically powered rotary molecular motor.

Journal of the American Chemical Society·2007
Same author

Synthesis of pterocellin A.

Organic letters·2006
Same author

Synthesis of the pyrazolo[4,3-e][1,2,4]triazine family of natural products: nostocine A, fluviol A, and pseudoiodinine.

Journal of the American Chemical Society·2006

Area of Science:

  • Organic Chemistry
  • Natural Product Synthesis

Background:

  • Cribrostatin 6 is a marine natural product with potential biological activity.
  • Efficient synthetic routes are crucial for studying and utilizing such compounds.

Purpose of the Study:

  • To describe a novel and efficient synthesis of cribrostatin 6.
  • To establish key chemical transformations for constructing the cribrostatin core structure.

Main Methods:

  • Regioselective bromination of an indole precursor.
  • Palladium-catalyzed biaryl coupling reaction.
  • Intramolecular cyclization to form the final product.

Main Results:

  • Successful synthesis of cribrostatin 6.
  • Demonstration of regioselective bromination and biaryl coupling in complex molecule synthesis.
  • Validation of intramolecular cyclization for ring formation.

Conclusions:

  • A viable synthetic route to cribrostatin 6 has been established.
  • The developed methodology provides a foundation for synthesizing cribrostatin analogs.
  • This synthesis highlights the utility of key organic reactions in natural product chemistry.

More Related Videos

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron

Published on: August 12, 2019

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
09:14

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

Related Experiment Videos

Last Updated: Jul 2, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron

Published on: August 12, 2019

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
09:14

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016