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Clinicopathological properties of poorly-differentiated adenocarcinoma of the stomach: comparison of solid- and
Chikara Kunisaki1, Hirotoshi Akiyama, Masato Nomura
1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan. s0714@med.yokohama-cu.ac.jp
Background:
The purpose of this study was to clarify the clinicopathological and biological properties of the poorly-differentiated types of gastric carcinoma (solid-type and non-solid-type).
Patients And Methods:
A total of 1,558 patients with primary gastric adenocarcinomas were enrolled in this study. The surgical results were compared.
Results:
Patients with non-solid-type tumors tended to be younger females with peritoneal or lymph node metastases and lymphatic invasion, and with tumors that were ill-defined, of larger diameter and deeper. Those patients with differentiated tumors tended to have the opposite characteristics of those patients with non-solid-type tumors. Patients with solid-type tumors had intermediate characteristics. The survival in patients with non-solid-type tumors was poor compared to those with differentiated or solid-type tumors. There was a significant difference in the survival of stage III tumors with either solid- or non-solid-type tumors (p=0.0480).
Conclusion:
Therapeutic strategies should be based on the histological type of the tumor in patients with poorly-differentiated gastric adenocarcinoma.