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A new twist in Smad signaling

Carl-Henrik Heldin1, Aristidis Moustakas

  • 1Ludwig Institute for Cancer Research, Uppsala University, Box 595, SE-751 24 Uppsala, Sweden.

Developmental Cell
|June 3, 2006
PubMed
Summary

Transforming growth factor-beta (TGFbeta) signaling relies on Smad4. New research shows transcriptional intermediary factor 1gamma (TIF1gamma) can bind to receptor-activated Smads (R-Smads) instead of Smad4, mediating distinct transcriptional outcomes.

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