Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in finger-aorta pressure transfer function during and after exercise.

Wim J Stok1, Berend E Westerhof, John M Karemaker

  • 1Department of Physiology, Academic Medical Center, University of Amsterdam, Rm. M01-214, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands. w.stok@amc.uva.nl

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 3, 2006
PubMed
Summary

Resting finger-aorta transfer functions (TF) provide unreliable central blood pressure estimates during exercise. Transfer functions shift with exercise, causing significant errors in systolic and diastolic pressure reconstruction, especially at higher heart rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to view the autonomic nervous system as physiologist, anatomist and pharmacologist?

The Journal of physiology·2026
Same author

Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.

Clinical neuropsychiatry·2026
Same author

Systolic BP Amplification: Systematic Review and Individual Participant Meta-Analysis.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Impaired autonomic cardiovascular control in people with HIV on long-term successful treatment.

AIDS (London, England)·2025
Same author

Case report: Extreme respiratory sinus arrhythmia in a non-athlete female student - a peculiar finding at the Physiology practicum.

Frontiers in neuroscience·2024
Same author

Baroreflex Sensitivity and Long-Term Dementia Risk in Older Adults.

Hypertension (Dallas, Tex. : 1979)·2024

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Noninvasive Monitoring

Background:

  • Noninvasive finger blood pressure measurements are increasingly used as a surrogate for central (aortic) blood pressure.
  • Transfer functions (TF) are mathematical models used to estimate central pressure from peripheral measurements.
  • The validity of these TFs during physiological stress, such as exercise, requires thorough investigation.

Purpose of the Study:

  • To assess the accuracy of finger-aorta transfer functions (TF) for reconstructing aortic pressure in cardiac patients during incremental bicycle exercise.
  • To evaluate how exercise affects the parameters of finger-aorta TFs and their impact on pressure waveform reconstruction.

Main Methods:

  • Seven cardiac patients underwent incremental bicycle exercise.

Related Experiment Videos

  • Simultaneous finger (Finapres) and aortic (catheter-tip manometer) pressures were recorded.
  • Autoregressive exogenous (ARX) models were used to calculate individual finger-aorta TFs at rest, during exercise, and post-exercise.

    • Main Results:

    • Applying rest-derived TFs during exercise led to significant underestimation of systolic pressure (+4.0 to -18.1 mmHg) and overestimation of diastolic pressure (-3.9 to +5.5 mmHg).
    • Pulse pressure estimation errors ranged from +4.5 to -21.9 mmHg, with noticeable wave distortion.
    • The frequency at which TF gain was minimal (Fmin) shifted significantly from rest (3.65–4.85 Hz) to maximal exercise (4.95–7.15 Hz), correlating with heart rate and delay.

    Conclusions:

    • Resting finger-aorta transfer functions become increasingly unreliable for reconstructing aortic pressure during incremental exercise, particularly at elevated heart rates.
    • The observed shifts in TF parameters during exercise indicate that static models are inadequate for dynamic physiological conditions.
    • Further research is needed to develop exercise-specific or adaptive TFs for accurate noninvasive central blood pressure monitoring during physical activity.