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Related Experiment Videos

The human obesity gene map: the 2005 update.

Tuomo Rankinen1, Aamir Zuberi, Yvon C Chagnon

  • 1Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA.

Obesity (Silver Spring, Md.)
|June 3, 2006
PubMed
Summary

This 12th update of the human obesity gene map details over 176 single-gene obesity cases and 253 human obesity quantitative trait loci (QTLs). It reviews 244 mouse obesity genes and 426 positive associations with 127 candidate genes.

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Area of Science:

  • Genetics
  • Obesity Research
  • Genomics

Background:

  • Obesity is a complex trait influenced by numerous genetic factors.
  • Understanding the genetic basis of obesity is crucial for developing effective interventions.
  • Previous updates have cataloged genetic discoveries related to obesity.

Purpose of the Study:

  • To present the 12th comprehensive update of the human obesity gene map.
  • To consolidate evidence from diverse genetic studies up to October 2005.
  • To provide a resource for researchers investigating the genetic underpinnings of obesity.

Main Methods:

  • Review of published literature up to October 2005.
  • Inclusion of data from single-gene mutation cases, Mendelian disorders, murine models, quantitative trait loci (QTLs) from animal and human studies, and association studies.

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  • Analysis of linkage data from genome scans.

    • Main Results:

    • 176 human obesity cases from 11 genes reported.
    • 50 loci for Mendelian syndromes related to obesity mapped.
    • 244 mouse genes affecting body weight identified.
    • 408 animal QTLs and 253 human obesity QTLs cataloged.
    • 52 genomic regions harbor multiple QTLs.
    • 426 positive associations between 127 candidate genes and obesity phenotypes identified.
    • 22 genes supported by at least five positive association studies.

    Conclusions:

    • The genetic landscape of human obesity is increasingly well-defined.
    • Multiple lines of evidence point to numerous genes and loci contributing to obesity.
    • The human obesity gene map continues to expand, highlighting its utility in genetic research.