Related Experiment Video
Updated: Aug 8, 2026

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
Published on: May 12, 2022
Malaria, anemia, and malnutrition in african children--defining intervention priorities
Stephan Ehrhardt1, Gerd D Burchard, Carsten Mantel
1Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. ehrhardt@bni-hamburg.de
Insights
Malnutrition is a key factor in childhood illness in sub-Saharan Africa, worsening malaria and anemia. Integrated malaria and nutrition programs are essential for reducing child morbidity.
Area of Science:
- Global Health
- Pediatrics
- Tropical Medicine
Background:
- Malaria, anemia, and malnutrition are significant contributors to childhood illness in sub-Saharan Africa.
- The complex interplay between these conditions requires further investigation.
Purpose of the Study:
- To investigate the interactions between malaria, anemia, and malnutrition in children.
- To determine the role of malnutrition in malaria-associated morbidity.
Main Methods:
- Conducted two surveys in northern Ghana in 2002, assessing over 4000 children.
- Evaluated plasmodial infection, anemia (hemoglobin <11 g/dL), and nutritional indices.
Main Results:
- Plasmodium infection was prevalent (82% rainy, 75% dry season).
- Anemia affected 64% of children, associated with age, season, residence, parasitemia, P. malariae, and malnutrition (OR 1.68).
- Malnutrition independently associated with fever (OR 1.59) and clinical malaria (OR 1.67).
Conclusions:
- Malnutrition is a fundamental factor in malaria-associated morbidity and anemia.
- Malaria control programs alone may be insufficient; combined nutrition programs are crucial for reducing childhood morbidity.
Background:
Malaria, anemia, and malnutrition contribute substantially to childhood morbidity in sub-Saharan Africa, but their respective roles and interactions in conferring disease are complex. We aimed to investigate these interactions.
Methods:
In 2002, we assessed plasmodial infection, anemia, and nutritional indices in 2 representative surveys comprising >4000 children in northern Ghana.
Results:
Infection with Plasmodium species was observed in 82% and 75% of children in the rainy and dry season, respectively. The fraction of fever attributable to malaria was 77% in the rainy season and 48% in the dry season and peaked in children of rural residence. Anemia (hemoglobin level, <11 g/dL) was seen in 64% of children and was, in multivariate analysis, associated with young age, season, residence, parasitemia, P. malariae coinfection, and malnutrition (odds ratio [OR], 1.68 [95% confidence interval [CI], 1.38-2.04]). In addition, malnutrition was independently associated with fever (axillary temperature, > or = 37.5 degrees C; OR, 1.59 [95% CI, 1.13-2.23]) and clinical malaria (OR, 1.67 [95% CI, 1.10-2.50]).
Conclusions:
Malnutrition is a fundamental factor contributing to malaria-associated morbidity and anemia, even if the latter exhibits multifactorial patterns. Our data demonstrate that malaria-control programs alone may not have the desired impact on childhood morbidity on a large scale without concomitant nutrition programs.
Related Concept Videos
Malaria
Anthelminthic Agents
Fungal Phylum Microsporidia
Antiprotozoal Agents
American Trypanosomiasis

