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[Etiological study on viral diarrhea among children in Lanzhou, Gansu, from July 2004 through June 2005]

Xin-hua Ye1, Yu Jin, Zhao-yin Fang

  • 1Department of Pediatrics, The First Hospital, Lanzhou University, Lanzhou 730000, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|June 6, 2006
PubMed

Insights

Rotavirus was the leading cause of acute diarrhea in Lanzhou children, followed by calicivirus, astrovirus, and adenovirus. The predominant rotavirus strain was P[4]G2, with frequent mixed viral infections observed.

Area of Science:

  • Virology
  • Molecular Epidemiology
  • Pediatric Infectious Diseases

Context:

  • Acute diarrhea remains a significant health concern for children globally.
  • Understanding the etiological agents of viral gastroenteritis is crucial for effective public health interventions.
  • Limited data exists on the molecular epidemiology of common enteric viruses in Lanzhou, Gansu province.

Purpose:

  • To investigate the molecular epidemiology of four major etiological viruses causing acute diarrhea in children under five years old in Lanzhou.
  • To identify the prevalence and specific strains of rotavirus, adenovirus, astrovirus, and calicivirus.
  • To analyze the characteristics of rotavirus and astrovirus strains, including serotype and P-genotype.

Summary:

  • A study of 400 pediatric patients with acute diarrhea in Lanzhou revealed rotavirus as the most prevalent pathogen (47.3%), followed by calicivirus (15.5%), astrovirus (9.5%), and adenovirus (7.5%).
  • Mixed viral infections were detected in 13.5% of cases. The predominant rotavirus strain was P[4]G2, a shift from previous years. Astrovirus serotype 1 was most common.
  • Viral diarrhea peaked from October to December, predominantly affecting children under two years, with the highest incidence in infants aged 6-23 months.

Impact:

  • This study provides critical epidemiological data on viral diarrhea in Lanzhou, informing targeted prevention and control strategies.
  • The identification of the predominant rotavirus strain (P[4]G2) is essential for vaccine efficacy monitoring and public health planning.
  • Findings highlight the importance of considering mixed viral infections in the diagnosis and management of acute pediatric diarrhea.
Abstract

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