Related Experiment Video
Updated: Aug 8, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Bone and bone related biochemical examinations. Hormone and hormone related substances. Parathyroid hormone]
Motoko Tanaka1, Masafumi Fukagawa
1Akebono Clinic, Department of Nephrology.
Abstract:
Parathyroid hormone (PTH) is the most important hormone to maintain serum calcium levels. PTH acts directly on bone by stimulating both bone resorption and bone formation with the reactive excess in the former when it acts continuously. PTH also acts on renal tubule to promote urinary excretion of phosphate as well as production active vitamin D (1,25 [OH] 2D) . 1,25 [OH] 2D has been also suggested to have some unique and direct action on the bone. Measurement of intact-PTH is essential for optimal management of bone abnormalities in patients with primary hyperparathyroidism, secondary hyperparathyroidism, and chronic kidney disease. The newer PTH assays ; whole-PTH and bio-intact PTH assay, use an antibody that binds the region including the first amino acid is present, making it specific for the complete molecule, (1-84)-PTH. Recently, a new molecular form of PTH has been reported, which cannot be detected by these newer PTH assays.
Related Concept Videos
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Skeleton and Calcium Homeostasis
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily regulated...
