Related Experiment Video
Updated: Aug 8, 2026

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants
Published on: November 3, 2019
[Mechanism of cartilage matrix remodeling by Wnt]
Takahito Yuasa1, Motomi Enomoto Iwamoto
1Thomas Jefferson University, Department of Orthopaedic Surgery.
Abstract:
Wnt proteins play central roles in a variety of developmental processes and regulate cell differentiation, cell fate and cell proliferation. It has been also demonstrated that Wnt proteins profoundly participate in cartilage development. Interestingly, activation of Wnt/beta-catenin signaling in chondrocytes induces a profile of matrix degradation enzymes quite similar to that of cartilage matrix degradation such as osteoarthritis and rheumatoid arthritis. In this review we discuss the involvement of Wnt/beta-catenin signaling in pathological cartilage matrix degradation.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Growth of Cartilage and Bone Tissue
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
