Related Experiment Video
Updated: Aug 8, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
An analysis of intra array repeats: the good, the bad and the non informative
Yedid Elbez1, Shlomit Farkash-Amar, Itamar Simon
1Faculté des Sciences de la vie., Université Louis Pasteur 28 rue Goethe., 67083 Strasbourg cedex, France. yedid.e@gmail.com
Background:
On most common microarray platforms many genes are represented by multiple probes. Although this is quite common no one has systematically explored the concordance between probes mapped to the same gene.
Results:
Here we present an analysis of all the cases of multiple probe sets measuring the same gene on the Affymetrix U133a GeneChip and found that although in the majority of cases both measurements tend to agree there are a significant number of cases in which the two measurements differ from each other. In these cases the measurements can not be simply averaged but rather should be handled individually.
Conclusion:
Our analysis allows us to provide a comprehensive list of the correlation between all pairs of probe sets that are mapped to the same gene and thus allows microarray users to sort out the cases that deserve further analysis. Comparison between the set of highly correlated pairs and the set of pairs that tend to differ from each other reveals potential factors that may affect it.
Related Concept Videos
Statistical Analysis: Overview
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
One-Way ANOVA
Variability: Analysis
The range is a simple measure of variability, indicating the difference between the highest and...
DNA Microarrays
What is an ANOVA?
Before performing ANOVA, one must ensure that the samples used for this analysis have three crucial characteristics or statistical assumptions. The first assumption states that the samples should be drawn from normally distributed samples, while the second requires that all the drawn samples should be randomly and...
What is ANOVA?
Before performing ANOVA, one must ensure that the samples used for this analysis have three crucial characteristics or statistical assumptions. The first assumption states that the samples should be drawn from normally distributed samples, while the second requires that all the drawn samples be randomly and independently...

