Two new triterpenoid glycosides from Cyclocarya paliurus

Area of Science:

• Natural Products Chemistry
• Phytochemistry
• Organic Chemistry

Background:

• Cyclocarya paliurus is a plant species known for its potential medicinal properties.
• Triterpenoid glycosides are a class of natural compounds with diverse biological activities.

Purpose of the Study:

• To isolate and characterize new dammarane triterpenoid glycosides from Cyclocarya paliurus.
• To elucidate the chemical structures of the isolated compounds.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation using Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy, including 2D-NMR (HMQC, HMBC, COSY, ROESY).

Main Results:

• Two new dammarane triterpenoid glycosides, named cyclocarosides B (1) and C (2), were successfully isolated.
• The complete structures of cyclocarosides B and C were determined, revealing specific glycosidic linkages and stereochemistry.

Conclusions:

• The study expands the knowledge of dammarane triterpenoid glycosides found in Cyclocarya paliurus.
• The identified compounds, cyclocarosides B and C, represent novel chemical entities with potential for further investigation.