Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraneuronal information processing, directional selectivity and memory for spatio-temporal sequences.

H Barlow1

  • 1Physiological Laboratory, University of Cambridge, Cambridge, CB2 3EG, UK.

Network (Bristol, England)
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Symptomatic glucocorticoid-induced adrenal suppression in the United Kingdom and Ireland: a BPSU study.

Archives of disease in childhood·2025
Same author

Control of IBMIR in neonatal porcine islet xenotransplantation in baboons.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Magnetic stimulation of the human retina.

Federation proceedings·2010
Same author

Failure of H 11 to Inhibit Growth of Tumours in Mice.

British medical journal·2010
Same author

Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2002
Same author

The exploitation of regularities in the environment by the brain.

The Behavioral and brain sciences·2002
Same journal

Enhancing IoT security: A Creative Swagger Optimization algorithm for DDoS defence.

Network (Bristol, England)·2026
Same journal

Parametric optimization for electrical discharge diamond grinding (EDDG) system using dual approach.

Network (Bristol, England)·2025
Same journal

A novel lung cancer diagnosis model using hybrid convolution (2D/3D)-based adaptive DenseUnet with attention mechanism.

Network (Bristol, England)·2025
Same journal

Hybrid optimization enabled Eff-FDMNet for Parkinson's disease detection and classification in federated learning.

Network (Bristol, England)·2025
Same journal

AI-driven plant disease detection with tailored convolutional neural network.

Network (Bristol, England)·2025
Same journal

Layer modified residual Unet++ for speech enhancement using Aquila Black widow optimizer algorithm.

Network (Bristol, England)·2025
See all related articles

Neurons may store spatio-temporal patterns of synaptic excitation using intracellular signaling. This allows individual neurons to recognize past activation patterns, potentially forming the basis for memory and response to phase sequences.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Signaling

Background:

  • Intracellular signaling pathways offer fine-grained computation distinct from neuronal interactions.
  • Understanding intraneuronal computations is key to a comprehensive model of brain function.

Purpose of the Study:

  • To propose that intraneuronal mechanisms compute and store spatio-temporal sequences of synaptic excitation.
  • To explore how neurons might recognize recurrent activation patterns.

Main Methods:

  • Analysis of experimental data on directionally selective neurons in the visual system.
  • Theoretical proposal for the role of calcium-induced calcium release (CICR) in the retina.
  • Hypothesizing Hebbian super-synapses for memory trace storage in the cortex.

Related Experiment Videos

Main Results:

  • Neurons integrate information along spatio-temporal trajectories, not separately in space and time.
  • Calcium-induced calcium release (CICR) is proposed as a mechanism for directional selectivity in the retina.
  • Hebbian super-synapses could store memory traces of synaptic delays, enabling phase sequence recognition.

Conclusions:

  • Intracellular signaling enables neurons to perform computations, including storing spatio-temporal excitation sequences.
  • Directional selectivity in the visual system may arise from intraneuronal mechanisms like CICR.
  • Synaptic plasticity mechanisms can support memory and response to complex temporal patterns.