Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Localisation of renin-angiotensin system (RAS) components in breast.

M Tahmasebi1, S Barker, J R Puddefoot

  • 1School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.

British Journal of Cancer
|June 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indo-Pacific Walker circulation drove Pleistocene African aridification.

Nature·2021
Same author

Introduction of an assessment toolkit associated with increased rate of DLB diagnosis.

Alzheimer's research & therapy·2021
Same author

Computer-aided detection for tuberculosis and silicosis in chest radiographs of gold miners of South Africa.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020
Same author

Early versus delayed surgery for paediatric supracondylar humeral fractures in the absence of vascular compromise: a systematic review and meta-analysis.

The bone & joint journal·2018
Same author

Sex, size and isotopes: cryptic trophic ecology of an apex predator, the white shark <i>Carcharodon carcharias</i>.

Marine biology·2018
Same author

Tracing of particulate organic C sources across the terrestrial-aquatic continuum, a case study at the catchment scale (Carminowe Creek, southwest England).

The Science of the total environment·2017

A tissue renin-angiotensin system (tRAS) is present in the human breast. Its components are disrupted in invasive breast cancer, suggesting a role in the disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Angiotensin II exhibits mitogenic and angiogenic properties, with widespread receptor distribution, especially in epithelial tissues.
  • Tissue renin-angiotensin systems (tRASs) are potential local sources of angiotensin II, mediating paracrine functions.
  • Understanding the tRAS in breast tissue is crucial for investigating its role in cancer development.

Purpose of the Study:

  • To investigate the presence and localization of a tRAS in normal human breast tissue and tumors.
  • To determine if tRAS components are involved in the progression of breast cancer.

Main Methods:

  • Immunocytochemistry and quantitative RT-PCR were employed.
  • Analysis focused on the presence and localization of renin-angiotensin system (RAS) components.

Related Experiment Videos

  • Investigated the potential involvement of RAS in breast cancer.

    • Main Results:

    • mRNA for angiotensinogen, prorenin, angiotensin converting enzyme (ACE), and AT1/AT2 receptors was detected in normal and diseased breast tissues.
    • (Pro)renin was found in epithelial cells of normal and diseased tissue, but diminished in invasive carcinoma.
    • Angiotensin converting enzyme (ACE) was present in epithelial cells of both normal and malignant tissues.

    Conclusions:

    • A functional tRAS exists in the human breast.
    • The tRAS is disrupted in invasive breast cancer, indicating its potential role in the disease's pathogenesis.
    • Further research into the tRAS's role in breast cancer is warranted.