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The relation between seborrheic keratoses and malignant solid tumours. A case-control study.

J J Grob1, M C Rava, J Gouvernet

  • 1Service de Dermatologie, Hôpital Ste Marguerite, Marseille, France.

Acta Dermato-Venereologica
|January 1, 1991
PubMed
Summary
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The Leser-Trelat sign, or sudden onset of seborrheic keratosis, is not reliably linked to solid tumors. This study found no significant association between cancer and seborrheic keratosis growth.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • The Leser-Trelat sign, characterized by eruptive seborrheic keratosis, has been anecdotally associated with internal malignancies.
  • Cherry angiomas have also been suggested as a potential paraneoplastic sign.

Purpose of the Study:

  • To investigate the association between solid tumors and the development of seborrheic keratosis.
  • To determine if cherry angiomas are regularly associated with solid tumors.

Main Methods:

  • A case-control study was conducted comparing 82 patients with recent solid tumors to 82 age- and sex-matched controls.
  • The number and characteristics of seborrheic keratosis lesions were assessed in both groups.

Main Results:

  • No significant differences were observed in the number or features of seborrheic keratosis between patients with solid tumors and controls.

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  • Eruptive seborrheic keratosis occurred in only one patient and one control.
  • Multiple cherry angiomas were not regularly associated with solid tumors.

    • Conclusions:

    • Solid malignancies are not generally associated with an increased incidence or altered features of seborrheic keratosis.
    • The Leser-Trelat sign is likely coincidental or a rare indicator of specific cancer types.
    • The association between cherry angiomas and solid tumors is not consistently observed.