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B cells and B cell products-helping to restore cellular immunity?

Marilia Cascalho1, Jeffrey L Platt

  • 1Transplantation Biology Program and the Departments Surgery, Immunology and Pediatrics, Mayo Clinic College of Medicine, Rochester, Minnesota.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|June 7, 2006
PubMed

T cells that provide vital protection against tumors, viruses and intracellular bacteria are thought to develop independently of B cells. However, recent discoveries suggest that development of T cells depends on B cells. One way B cells promote T cell development is by providing diverse peptides that may promote positive selection of thymocytes. Diverse peptides and B cells help in diversification of the T cell receptor repertoire and may decrease cross-reactivity in the mature T cell compartment. These new insights may provide the basis for the design of novel therapeutics.

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