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Long-Term Home Storage of Autologous Serum Eye Drops
Grit Waitz1, Ibrahim Alhaj Sakor1, Wendy Bergmann-Ewert2
1Institute of Transfusion Medicine, University Medicine Rostock, Rostock, Germany.
Summary
Autologous serum eye drops (ASEDs) remain stable for up to 148 days when stored at home freezing temperatures. This study confirms the feasibility of using ASEDs for dry eye syndrome treatment under typical home storage conditions.
Area of Science:
- Ophthalmology
- Biochemistry
- Cryobiology
Background:
- Autologous serum eye drops (ASEDs) are a treatment for dry eye syndrome.
- ASEDs are prepared from a patient's own blood and typically stored frozen at home.
Purpose of the Study:
- To assess the sterility, particle count, protein concentration, and growth factor stability of ASEDs stored for 148 days at -10°C.
- To determine the feasibility of home storage for ASEDs.
Main Methods:
- Analysis of sterility, particle number, protein concentration.
- Quantification of 14 growth factors using methods like 1D-SDS-PAGE.
- Storage of ASED samples at -10°C for 148 days.
Main Results:
- Total protein concentration remained stable, indicating no significant degradation.
- Concentrations of angiopoietin-2, vascular endothelial growth factor, platelet-derived growth factor, and hepatocyte growth factor slightly increased.
- Stem cell factor concentration showed a modest decrease, while other factors remained largely stable.
Conclusions:
- ASEDs can be stored under typical home freezing conditions for up to 148 days.
- The study supports the clinical feasibility of using home-stored ASEDs for dry eye syndrome treatment.
