Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver function tests and neuropsychologic impairment in substance abusers.

E D Richardson1, P F Malloy, R Longabaugh

  • 1Butler Hospital, Providence, RI 02906.

Addictive Behaviors
|January 1, 1991
PubMed
Summary

Elevated liver enzymes like gamma-glutamyl transferase (GGT) in alcoholics correlate with poorer cognitive function during treatment. This suggests liver health impacts brain recovery in alcoholism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The time and change test: a simple screening test for dementia.

The journals of gerontology. Series A, Biological sciences and medical sciences·2008
Same author

Confidence in, and self-rating of, driving ability among older drivers.

Accident; analysis and prevention·1998
Same author

Development of a test battery to identify older drivers at risk for self-reported adverse driving events.

Journal of the American Geriatrics Society·1998
Same author

The effect of estrogen replacement therapy on cognitive function in women: a critical review of the literature.

Journal of clinical epidemiology·1997
Same author

A predictive model for ADL dependence in community-living older adults based on a reduced set of cognitive status items.

Journal of the American Geriatrics Society·1997
Same author

Long-term cognitive sequelae of cerebral malaria in Vietnam veterans.

Applied neuropsychology·1997

Area of Science:

  • Neuroscience
  • Hepatology
  • Addiction Medicine

Background:

  • Alcoholism is associated with significant neuropsychological deficits.
  • Liver dysfunction is common in individuals with alcohol use disorder.
  • The interplay between liver function and cognitive impairment in early recovery is not fully understood.

Purpose of the Study:

  • To investigate the relationship between liver enzyme levels and residual neuropsychological dysfunction in recently treated alcoholics.
  • To determine if liver function, specifically gamma-glutamyl transferase (GGT) levels, predicts cognitive deficits.

Main Methods:

  • Studied noncirrhotic alcoholics undergoing acute treatment.
  • Assessed participants using neuropsychological tests measuring visuoperceptual and conceptual abilities.

Related Experiment Videos

  • Measured serum gamma-glutamyl transferase (GGT) levels to assess liver function.

    • Main Results:

    • Alcoholics with extremely high GGT levels showed significantly greater impairments in visuoperceptual and conceptual tasks compared to those with normal or mildly elevated GGT.
    • This association between liver dysfunction and cognitive impairment was independent of patient age and drinking patterns.

    Conclusions:

    • Subtle liver dysfunction, indicated by elevated GGT, is linked to persistent cognitive deficits in alcoholics.
    • These findings highlight the importance of monitoring liver function for treatment planning and prognosis in alcoholic patients.
    • Addressing liver health may be crucial for improving neuropsychological recovery in alcoholism.