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Updated: Jul 16, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
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Published on: April 10, 2015

Highly efficient atom transfer radical addition reactions with a RuIII complex as a catalyst precursor.

Laurent Quebatte1, Katrin Thommes, Kay Severin

  • 1Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Journal of the American Chemical Society
|June 8, 2006
PubMed
Summary

A novel ruthenium catalyst, [Cp*RuCl2(PPh3)], combined with azobisisobutyronitrile (AIBN), efficiently catalyzes atom transfer radical addition reactions. This method achieves high turnover numbers for adding polychlorinated compounds and sulfonyl chlorides to olefins.

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Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

Published on: August 23, 2018

Area of Science:

  • Organometallic Chemistry
  • Radical Chemistry
  • Catalysis

Background:

  • Atom transfer radical addition (ATRA) is a valuable synthetic tool.
  • Developing efficient catalysts for ATRA reactions remains an active area of research.
  • Polychlorinated compounds and sulfonyl chlorides are important building blocks in organic synthesis.

Purpose of the Study:

  • To investigate the catalytic activity of an air-stable Ru(III) complex for ATRA reactions.
  • To explore the scope of the developed catalytic system with various substrates.
  • To achieve high efficiency and turnover numbers in ATRA reactions.

Main Methods:

  • Utilized the air-stable Ru(III) complex [Cp*RuCl2(PPh3)] as a catalyst.
  • Employed azobisisobutyronitrile (AIBN) as a radical initiator.
  • Investigated the atom transfer radical addition of polychlorinated compounds and sulfonyl chlorides to olefins.

Main Results:

  • The [Cp*RuCl2(PPh3)]/AIBN system effectively catalyzed ATRA reactions.
  • Achieved unprecedented turnover numbers (TONs) up to 44,000.
  • Demonstrated the utility of the catalyst for functionalizing olefins with diverse chlorinated compounds.

Conclusions:

  • The developed ruthenium-catalyzed ATRA reaction offers a highly efficient method for C-C and C-heteroatom bond formation.
  • The air-stable nature of the catalyst and high TONs make this a practical and scalable synthetic approach.
  • This work expands the catalytic toolbox for radical additions using readily available reagents.