Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug therapy persistence and stroke recurrence.

Fadia T Shaya1, Antoine C El Khoury, C Daniel Mullins

  • 1Department of Epidemiology and Preventive Medicine, University of Maryland, 515 West Lombard St, Baltimore, MD 21201, USA. fshaya@rx.umaryland.edu

The American Journal of Managed Care
|June 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Scoping Review of Toolkits Addressing Ethical Issues in Health Registry and Clinical Research Enrollment Among African Americans With CKD.

Kidney medicine·2026
Same author

Incremental health care resource utilization, costs, and predictors of high costs in generalized myasthenia gravis.

Journal of managed care & specialty pharmacy·2026
Same author

Development of consensus criteria for problematic medications in active duty service members.

Journal of the American Pharmacists Association : JAPhA·2026
Same author

Efficacy and Safety of Lumateperone and Other Atypical Antipsychotics Approved as Adjunctive Treatment for Major Depressive Disorder in the United States: A Network Meta-Analysis.

Advances in therapy·2026
Same author

A Multisite, Randomized Trial Testing a Community-Digital Health Intervention among Black and Latino Adults with Cardiometabolic Conditions: The Roots of Wellness (Raíces del Bienestar) Protocol.

medRxiv : the preprint server for health sciences·2026
Same author

Invasive E. coli Disease in US Nursing Homes: Brief Report of Case Validation Findings.

Journal of the American Geriatrics Society·2026
Same journal

Prescription drug prior authorization: costs to pharmacies and physicians.

The American journal of managed care·2026
Same journal

Combined pharmacotherapy and psychotherapy impact on opioid use disorder treatment.

The American journal of managed care·2026
Same journal

The societal costs of food insecurity: implications for managed care strategies.

The American journal of managed care·2026
Same journal

Availability of hospital financial assistance documents in non-English languages.

The American journal of managed care·2026
Same journal

Real-world weight loss with injectable semaglutide vs dulaglutide for diabetes.

The American journal of managed care·2026
Same journal

Social needs screening and supplemental benefits in Medicare Advantage.

The American journal of managed care·2026
See all related articles

Consistent use of stroke medications like warfarin, aspirin, or clopidogrel significantly reduces stroke recurrence risk. However, conditions such as heart disease and hypertension increase recurrence likelihood.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Stroke recurrence is a significant concern, particularly in high-risk populations.
  • Understanding medication adherence impact on secondary stroke prevention is crucial.

Purpose of the Study:

  • To evaluate the effect of persistent use of warfarin, aspirin, or clopidogrel on stroke recurrence.
  • To analyze these effects in a Medicaid population characterized by high risk, female predominance, and African American ethnicity.

Main Methods:

  • A prospective, non-concurrent cohort study utilizing longitudinal medical and pharmacy claims data.
  • Cox proportional hazards models and propensity scores were employed to analyze medication persistence and adjust for confounding factors.

Main Results:

Related Experiment Videos

  • Persistence in using warfarin, aspirin, or clopidogrel was associated with an increased likelihood of avoiding stroke recurrence (HR, 1.57; 95% CI, 1.22-2.01).
  • Initial hemorrhagic stroke, heart disease, hypertension, and diabetes mellitus were significantly associated with a decreased likelihood of avoiding recurrence.

Conclusions:

  • Sustained use of initial stroke-preventive medications is effective in preventing recurrent strokes.
  • Certain comorbidities and stroke types (hemorrhagic) are significant risk factors for stroke recurrence.