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Updated: Aug 8, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane
Jonathan N Sachs1, Donald M Engelman
1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA. jsachs@csb.yale.edu
Abstract:
In our review, we introduce an organizational scheme for membrane protein function. It is the relationship between structure, dynamics, and environment that endows the membrane and its constituents with remarkable sensitivity and robustness. Our understanding begins with landmark advances like those presented in the following chapters. Membrane proteins are notoriously difficult to study, and so the work presented here on the ADP/ATP carrier [Nury et al. ( 2 )], rhodopsin [Palczewski ( 24 )], and the cytochrome b6f complex [Cramer et al. ( 35 )] represents incredible progress in this now blossoming field.
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