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Acute cholecystitis accompanied by acute pancreatitis potentially caused by Dolosigranulum pigrum

Jung-Chung Lin1, Shu-Jin Hou, Li-Ung Huang

  • 1Division of Infectious Diseases and Tropical Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan, Republic of China.

Journal of Clinical Microbiology
|June 8, 2006
PubMed

Insights

A rare case of acute cholecystitis and pancreatitis caused by Dolosigranulum pigrum in a patient with gallstones was successfully treated. This finding highlights D. pigrum as a potential pathogen in biliary tract infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Gastroenterology

Background:

  • Gallstones are a common cause of cholecystitis and pancreatitis.
  • Dolosigranulum pigrum is a rare pathogen, typically associated with endocarditis.

Observation:

  • A 76-year-old male with gallstones presented with acute cholecystitis and acute pancreatitis.
  • Blood cultures revealed Dolosigranulum pigrum.

Findings:

  • D. pigrum was identified using biochemical tests and 16S rRNA sequencing.
  • The bacterial isolate was susceptible to multiple antibiotics, including beta-lactams, chloramphenicol, and vancomycin.
  • The patient received a two-week course of appropriate antibiotics.

Implications:

  • This case expands the spectrum of clinical manifestations associated with D. pigrum infections.
  • Highlights the importance of considering rare bacteria in polymicrobial infections.
  • Suggests D. pigrum can be a causative agent in biliary tract infections, particularly in patients with gallstones.

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