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[Escherichia coli a forgotten pathogen in septicemia].
Anna Sledzińska1, Alfred Samet, Marek Bronk
1Laboratorium Mikrobiologii Klinicznej Samodzielnego Publicznego Szpitala Klinicznego nrl Akademickie Centrum Kliniczne Akademii Medycznej w Gdańsku.
Przeglad Epidemiologiczny
|June 9, 2006
Summary
Escherichia coli (E. coli) bacteremia occurred in 8.0% of patients, with a 11.2% mortality rate within 48 hours. The Hematology Unit showed the highest incidence, with genitourinary and gastrointestinal tracts as primary infection sources.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Bacteremia, particularly E. coli bacteremia, poses a significant threat in hospital settings.
- Understanding incidence, outcomes, and antimicrobial resistance patterns is crucial for effective patient management.
Purpose of the Study:
- To analyze the incidence, patient outcomes, infection sources, and antimicrobial susceptibility of E. coli bacteremia.
- To identify high-risk units and common entry points for E. coli infections.
Main Methods:
- Retrospective study analyzing data from eight wards at SPSK 1 ACK AM in Gdansk.
- Data collected from 2002 to 2004, including patient outcomes, infection sources, and antimicrobial susceptibility testing.
Main Results:
- 268 cases of E. coli bacteremia were identified (8.0% of all bacteremic patients).
- Mortality within 24-48 hours was 11.2%.
- The Hematology Unit had the highest incidence (33.2/1000 patients). Genitourinary (24.3%) and gastrointestinal (21.8%) tracts were the main sources.
- E. coli strains showed low susceptibility to ampicillin (33.3%), co-trimoxazole (68.4%), amoxicillin/clavulanic acid (69.3%), and ciprofloxacin (78.9%).
Conclusions:
- E. coli bacteremia is a notable cause of bloodstream infections with significant mortality.
- Targeted interventions in high-incidence units like Hematology are warranted.
- Antimicrobial stewardship programs should consider local resistance patterns, particularly for commonly used antibiotics.