Related Experiment Videos

[Study on the correlation of vitamin A and iron status in children]

Jian-hong Li1, Jian-hua Piao, Ning Guo

  • 1Institute for Nutrition and Food Safety, Chinese CDC, Beijing 100050, China.

Insights

Vitamin A (VA) deficiency and marginal deficiency are prevalent in Chinese children, affecting 8.4% and 44.7% respectively. Plasma VA levels correlate with iron status, indicating a coexisting nutritional challenge.

Area of Science:

  • Nutritional Science
  • Pediatric Health
  • Public Health

Background:

  • Vitamin A (VA) is crucial for immune function and vision.
  • Iron deficiency is a common nutritional problem in children globally.
  • Assessing the combined nutritional status is vital for effective public health interventions.

Purpose of the Study:

  • To determine vitamin A status in Chinese children.
  • To investigate the prevalence of vitamin A deficiency and marginal deficiency.
  • To explore the relationship between vitamin A and iron status.

Main Methods:

  • Analysis of data from the 2002 Chinese National Health and Nutrition Survey (CNHS).
  • Measurement of plasma vitamin A, hemoglobin, ferritin, TIBC, and sTfR in 380 children.
  • Statistical analysis to assess deficiency prevalence and correlations.

Main Results:

  • The prevalence of vitamin A deficiency was 8.4%, and marginal deficiency was 44.7%.
  • Plasma vitamin A showed a positive correlation with hemoglobin (r=0.16986, P<0.01).
  • Plasma vitamin A was negatively correlated with soluble transferrin receptor (r=-0.12863, P<0.05), but not with ferritin or TIBC.

Conclusions:

  • Vitamin A deficiency and marginal deficiency are widespread among Chinese children.
  • Iron deficiency coexists with vitamin A marginal deficiency in this population.
  • Plasma vitamin A levels are significantly correlated with key indicators of iron status.
Abstract

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...