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In-patient withdrawal from long-term benzodiazepine use
British Journal of Addiction
|April 1, 1991
Summary
Withdrawal from long-term benzodiazepine dependence is challenging. A study found that while some patients achieve good outcomes, depression and older age are associated with poorer results, suggesting maintenance may be better for some.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Long-term benzodiazepine use can lead to dependence.
- Withdrawal from benzodiazepines presents significant challenges for patients.
Purpose of the Study:
- To evaluate the outcomes of an intensive group-based program for benzodiazepine withdrawal.
- To identify factors associated with successful or unsuccessful withdrawal.
Main Methods:
- An intensive in-patient and out-patient group-based program was implemented.
- Twenty-one patients with long-term benzodiazepine dependence completed the program.
- Outcomes were assessed at 6-month follow-up post-withdrawal.
Main Results:
- 38% of patients achieved a 'good' outcome at 6-month follow-up.
- Depressive disorders were linked to poorer outcomes compared to anxiety disorders.
- Older patients and those with depression experienced less favorable withdrawal results.
- Two patients died by suicide post-withdrawal.
Conclusions:
- Benzodiazepine withdrawal is associated with significant challenges, including psychiatric morbidity and mortality.
- Maintenance benzodiazepine prescription may be a preferable option for certain dependent patients.
- Further research is needed to understand the complex relationship between depression and benzodiazepine withdrawal.