Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioral evaluation of movement cancellation.

Mark M G Walton1, Neeraj J Gandhi

  • 1Department of Otolaryngology, University of Pittsburgh, Eye and Ear Institute, Pittsburgh, PA 15213, USA.

Journal of Neurophysiology
|June 9, 2006
PubMed
Summary

Researchers used air-puff blinks to directly measure stop signal reaction time (SSRT) during a saccade task. This method validates current statistical SSRT estimation techniques used in eye movement research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct neural geometries for target position and velocity in the primate superior colliculus.

bioRxiv : the preprint server for biology·2026
Same author

Investigating the mechanisms underlying saccade generation in the frontal eye fields using multisite microstimulation.

Journal of neurophysiology·2026
Same author

Drifting population dynamics with transient resets characterize sensorimotor transformation in the monkey superior colliculus.

Communications biology·2026
Same author

Investigating the mechanisms underlying saccade generation in the frontal eye fields using multi-site microstimulation.

bioRxiv : the preprint server for biology·2026
Same author

Saccade-Related Activity in Superior Colliculus Predicts Eye Choice for Goal-Directed Saccades in Monkeys With Strabismus.

Investigative ophthalmology & visual science·2025
Same author

Edward Lowell Keller (1939-2025).

Nature neuroscience·2025

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Ophthalmology

Background:

  • The countermanding saccade task investigates the neural basis of movement inhibition.
  • Stop signal reaction time (SSRT) is crucial but typically estimated indirectly.
  • Current SSRT estimation methods lack definitive validation.

Purpose of the Study:

  • To develop a more direct method for measuring SSRT.
  • To validate existing statistical approaches for SSRT estimation.
  • To investigate the neural mechanisms of saccade execution and cancellation.

Main Methods:

  • Rhesus monkeys performed a countermanding saccade task.
  • Air-puff-evoked blinks were used to "unmask" developing motor commands.
  • Blink timing relative to target and stop cue onset was analyzed.
  • Monte Carlo simulations modeled blink effects on the race model.

Main Results:

  • Blinks between 50-200 ms post-target onset often evoked saccades.
  • Saccades were rarely evoked >70 ms after stop cue onset, providing a behavioral SSRT estimate.
  • This behavioral SSRT matched estimates from standard statistical methods.
  • Saccades near the SSRT on blink trials were frequently hypometric.

Conclusions:

  • Air-puff-evoked blinks offer a direct measure of SSRT.
  • The study validates the statistical methods currently used for SSRT estimation.
  • Findings support the race model of action execution and inhibition.

Related Experiment Videos