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Related Experiment Video

Updated: Jun 19, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Investigating the mechanisms underlying saccade generation in the frontal eye fields using multisite

Richard Johnston1, Roma O Konecky1, Husam A Katnani2

  • 1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Journal of Neurophysiology
|June 18, 2026
PubMed
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Electrical microstimulation of the frontal eye field (FEF) in monkeys reveals how current intensity affects saccade direction and amplitude. A novel polar average model better predicts dual-site stimulation effects on saccades.

Area of Science:

  • Neuroscience
  • Oculomotor Research
  • Computational Neuroscience

Background:

  • The frontal eye field (FEF) is crucial for controlling eye movements, with electrical microstimulation reliably evoking saccades.
  • Understanding how microstimulation parameters influence saccades and how FEF population activity is decoded remains a challenge.

Purpose of the Study:

  • To investigate the influence of microstimulation parameters on evoked saccades in the FEF.
  • To compare different models for predicting saccade characteristics during dual-site FEF stimulation.
  • To explore how the brain integrates FEF information for saccadic planning.

Main Methods:

  • Used a 16-channel microelectrode array for microstimulation in the FEF of awake, behaving monkeys.
  • Varied current intensities and stimulation sites (single vs. dual contacts).
Keywords:
cerebral cortexelectrical stimulationrhesus macaquesuperior colliculus

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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

  • Developed and tested a polar average model against traditional vector sum and average models using FEF and superior colliculus (SC) data.

    • Main Results:

    • Higher current intensities were needed to alter saccade direction compared to amplitude during single-site FEF stimulation.
    • The polar average model outperformed traditional models in predicting both amplitude and direction of dual-site saccades.
    • In the SC, the polar average model improved saccade amplitude prediction but not direction prediction.
    • Model accuracy for unequal dual-site stimulation depended on individual site saccade amplitudes, suggesting flexible integration of FEF information.

    Conclusions:

    • Saccade direction and amplitude are differentially affected by FEF microstimulation intensity.
    • A polar average model offers a more accurate framework for understanding FEF population activity readout for saccade generation.
    • The brain appears to flexibly combine saccadic amplitude and direction information from the FEF for motor planning.