Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebral Hemispheres01:05

Cerebral Hemispheres

3.7K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
3.7K
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

6.3K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
6.3K
Lateralization01:28

Lateralization

1.3K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.3K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

6.1K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
6.1K
Organization of the Brain01:30

Organization of the Brain

3.9K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the mechanisms underlying saccade generation in the frontal eye fields using multi-site microstimulation.

Journal of neurophysiology·2026
Same author

Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.

eLife·2026
Same author

Input-dependent directionality of interactions between cortical areas.

bioRxiv : the preprint server for biology·2026
Same author

Linking reaction time variability to physiological markers of arousal across timescales.

bioRxiv : the preprint server for biology·2026
Same author

From Breath to Behavior: Respiratory Features Predict Visual Detection Performance.

bioRxiv : the preprint server for biology·2026
Same author

The role of the locus coeruleus in eye movements during perceptual decision making.

bioRxiv : the preprint server for biology·2026
Same journal

Plasmonic nanocomposite helices for weather-adaptive LiDAR function.

Nature communications·2026
Same journal

Multidirectional strain-insensitive stretchable RF electronics.

Nature communications·2026
Same journal

In-scanner thoughts contribute to resting-state functional connectivity.

Nature communications·2026
Same journal

Metal-center electron affinity modulates multicolor electrochromism in 2D conjugated metal-organic frameworks.

Nature communications·2026
Same journal

Hyperbranched dielectric polymer networks exhibiting giant energy storage density at 250 °C.

Nature communications·2026
Same journal

3D nanoprinting of metals by spatiotemporally confined hot electrons via multiple-electron excitations in nanocrystals.

Nature communications·2026
See all related articles
  1. Home
  3. Interactions Across Hemispheres In Prefrontal Cortex Reflect Global Cognitive Processing.
  1. Home
  3. Interactions Across Hemispheres In Prefrontal Cortex Reflect Global Cognitive Processing.

Related Experiment Video

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.4K

Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.

Megan E McDonnell1,2, Akash Umakantha1,2,3, Ryan C Williamson1,2,3,4

  • 1Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.

Nature Communications
|April 11, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study reveals that brain-wide arousal signals significantly influence neuronal activity across different brain areas during memory tasks. Advanced statistical methods uncovered shared neural variability, highlighting the importance of multi-area recordings for understanding brain function.

More Related Videos

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.4K
Central and Divided Visual Field Presentation of Emotional Images to Measure Hemispheric Differences in Motivated Attention
05:36

Central and Divided Visual Field Presentation of Emotional Images to Measure Hemispheric Differences in Motivated Attention

Published on: November 16, 2017

8.0K

Related Experiment Videos

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.4K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.4K
Central and Divided Visual Field Presentation of Emotional Images to Measure Hemispheric Differences in Motivated Attention
05:36

Central and Divided Visual Field Presentation of Emotional Images to Measure Hemispheric Differences in Motivated Attention

Published on: November 16, 2017

8.0K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Brain functions rely on local neural networks and global signals like arousal.
  • Understanding neural interactions between brain areas is crucial for dissecting complex cognitive functions.
  • Previous studies often focused on single brain areas, limiting insights into inter-areal communication.

Purpose of the Study:

  • To investigate neural interactions between prefrontal cortex areas in both hemispheres during a spatial memory task.
  • To differentiate between local neural processing and global modulatory influences on neuronal activity.
  • To develop and apply novel statistical methods for analyzing multi-area neural recordings.

Main Methods:

  • Dual hemisphere recordings of prefrontal cortex activity in monkeys performing a spatial memory task.
  • Application of a novel statistical approach, probabilistic canonical correlation analysis with factor analysis (pCCA-FA).
  • Analysis of trial-to-trial variability in neuronal activity to identify shared and distinct neural signals.

    • Main Results:

    • Significant shared variability was found among neurons within individual prefrontal cortex populations.
    • A substantial portion of this shared variability was common across both hemispheres.
    • The cross-hemispheric shared variability was strongly linked to an arousal process.
    • The findings suggest that arousal modulates neural activity across distant brain regions.

    Conclusions:

    • Multi-area recordings, analyzed with advanced statistical techniques, can reveal brain functions obscured in single-area studies.
    • Arousal plays a critical role in coordinating activity across widespread neural populations during cognitive tasks.
    • The study provides a framework for leveraging simultaneous recordings from multiple brain regions to understand neural communication and function.