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Lipophagic panniculitis in re-excision specimens.

B D Zelickson1, R K Winkelmann

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Acta Dermato-Venereologica
|January 1, 1991
PubMed
Summary

Lipophagic panniculitis, characterized by macrophages in subcutaneous tissue, can be a normal wound healing response. This finding was observed in re-excision skin biopsy specimens, suggesting it is not always indicative of Weber-Christian disease.

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Area of Science:

  • Dermatopathology
  • Histopathology
  • Subcutaneous tissue disorders

Background:

  • Lipophagic panniculitis involves macrophage infiltration and foam cell transformation in subcutaneous tissue.
  • These pathological features have been historically associated with Weber-Christian disease diagnosis.

Purpose of the Study:

  • To investigate the occurrence and significance of lipophagic panniculitis in re-excision specimens.
  • To determine if lipophagia in this context represents a normal wound healing response.

Main Methods:

  • Analysis of 252 re-excision specimens from previously biopsied skin tumors.
  • Histopathological examination to identify lipophage infiltration, foam cells, giant cells, suture material, hair, granulation tissue, and phlebitis.

Main Results:

  • Five cases of lipophagic panniculitis were identified in re-excision specimens.
  • Infiltrates were localized near initial biopsy sites, often associated with suture material, hair, granulation tissue, and foreign body giant cells.
  • Phlebitis was noted in proximity to the infiltration in four cases; no patients developed symptomatic panniculitis.

Conclusions:

  • Lipophagia observed in re-excision specimens can be a manifestation of normal wound healing.
  • The presence of lipophagic panniculitis in this setting does not necessarily indicate Weber-Christian disease.

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