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Related Experiment Videos

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis.

J C Ameisen1, A Capron

  • 1Centre d'Immunologie et de Biologie Parasitaire, INSERM U 167-CNRS 624, Institut Pasteur, Lille, France.

Immunology Today
|April 1, 1991
PubMed
Summary
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Inappropriate programmed cell death may cause helper T-cell defects in HIV patients. This model explains AIDS pathogenesis, disease progression, and organ damage in HIV infection.

Area of Science:

  • Immunology
  • Virology
  • Pathogenesis

Background:

  • Normal thymocytes undergo programmed cell death (apoptosis) for T-cell repertoire selection.
  • Human Immunodeficiency Virus (HIV) infection leads to helper T-cell defects.

Purpose of the Study:

  • To propose that inappropriate programmed T-cell death contributes to HIV-associated T-cell dysfunction.
  • To present a model of Acquired Immunodeficiency Syndrome (AIDS) pathogenesis.

Main Methods:

  • Review and theoretical modeling of T-cell apoptosis in HIV infection.
  • Analysis of disease progression and organ defects in AIDS.

Main Results:

  • Inappropriate induction of programmed T-cell death is hypothesized to cause helper T-cell defects.

Related Experiment Videos

  • The proposed model may explain qualitative and quantitative T-cell deficiencies.

    • Conclusions:

    • Programmed T-cell death offers a potential explanation for T-cell defects in HIV/AIDS.
    • The model may elucidate AIDS pathogenesis, disease evolution, and non-immunological organ damage.