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Benzodiazepines: abuse and new use.

L B Warneke1

  • 1University of Alberta, Department of Psychiatry, Edmonton.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|April 1, 1991
PubMed
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Benzodiazepines are safe and have low abuse potential when prescribed correctly. This review covers their uses, risks, and safe prescribing practices for conditions like panic disorder.

Area of Science:

  • Pharmacology and Therapeutics
  • Psychiatry

Background:

  • Benzodiazepines are widely prescribed medications.
  • Concerns exist regarding their potential for abuse and dependence.
  • Understanding their pharmacology is crucial for safe use.

Purpose of the Study:

  • To review the pharmacology of benzodiazepines.
  • To differentiate between abuse, rebound, recurrence, and withdrawal.
  • To explore new therapeutic applications and provide guidance on rational prescribing.

Main Methods:

  • Literature review of benzodiazepine pharmacology and clinical use.
  • Analysis of data on benzodiazepine abuse and dependence.
  • Examination of evidence for new indications.

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Main Results:

  • Benzodiazepines are generally safe with negligible abuse potential when used appropriately.
  • Dangers of alternatives like alcohol and barbiturates are highlighted.
  • New uses include panic disorder, mania, and psychotic states.

Conclusions:

  • Rational prescribing and careful monitoring are essential for benzodiazepine therapy.
  • The perception of benzodiazepines as inherently dangerous and addictive is discouraged.
  • Emphasize the safety profile when used for appropriate indications.