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Single photon emission computerized tomography in obsessive compulsive disorder: a preliminary study

B L Adams1, L B Warneke, A J McEwan

  • 1Department of Psychiatry, University of Alberta, Edmonton, Canada.

Journal of Psychiatry & Neuroscience : JPN
|May 1, 1993
PubMed
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Obsessive compulsive disorder (OCD) patients often show impaired cerebral perfusion, particularly in the basal ganglia. This study used SPECT imaging to reveal asymmetric blood flow patterns in OCD individuals, highlighting potential neurobiological underpinnings.

Area of Science:

  • Neuroscience
  • Radiology
  • Psychiatry

Background:

  • Obsessive compulsive disorder (OCD) is a complex mental health condition.
  • Neuroimaging studies aim to understand the brain's functional and structural abnormalities in OCD.

Purpose of the Study:

  • To investigate cerebral perfusion patterns in patients diagnosed with obsessive compulsive disorder.
  • To correlate perfusion abnormalities with symptom severity in OCD.

Main Methods:

  • Utilized single photon emission computerized tomography (SPECT) with 99m-Tc-HMPAO radiotracer.
  • Evaluated 11 patients meeting DSM-III-R criteria for OCD.
  • Assessed symptom severity using the Yale-Brown Obsessive Compulsive Scale.
  • Employed blinded qualitative and semi-quantitative image analysis by a nuclear medicine physician.

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Main Results:

  • Asymmetric cerebral perfusion was observed in 8 out of 11 OCD patients.
  • Impaired perfusion was predominantly noted on the left side of the basal ganglia in six patients.
  • SPECT imaging revealed distinct perfusion patterns in the basal ganglia of OCD individuals.

Conclusions:

  • Cerebral perfusion asymmetry, especially in the basal ganglia, is a notable finding in patients with obsessive compulsive disorder.
  • These perfusion patterns may indicate underlying neurobiological alterations contributing to OCD.
  • SPECT imaging offers valuable insights into the pathophysiology of OCD.