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Related Experiment Video

Updated: Jul 17, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

PUVA and cancer: a large-scale epidemiological study.

B Lindelöf¹, B Sigurgeirsson, E Tegner

¹Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Lancet (London, England)

|July 13, 1991

Summary

Psoralen and ultraviolet A radiation (PUVA) therapy for skin disorders may increase cancer risk. A Swedish study found a dose-dependent rise in squamous cell cancer, especially with over 200 treatments.

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Area of Science:

Dermatology
Oncology
Phototherapy Research

Background:

Concerns exist regarding the long-term carcinogenic effects of psoralen and ultraviolet A radiation (PUVA) therapy.
PUVA is a common treatment for various skin disorders.

Purpose of the Study:

To investigate the association between PUVA therapy and the risk of developing specific cancers.
To evaluate the dose-dependent relationship between PUVA treatment and cancer incidence.

Main Methods:

A cohort study of 4799 Swedish patients treated with PUVA between 1974 and 1985.
Analysis of cancer incidence in relation to the number of PUVA treatments received and patient demographics.
Follow-up periods averaged 6.9 years for males and 7.2 years for females.

Main Results:

A significant dose-dependent increase in the risk of squamous cell cancer of the skin was observed.
Male patients receiving over 200 PUVA treatments showed a >30-fold increased incidence of squamous cell cancer compared to the general population.
Elevated incidences of respiratory cancer (males and females), pancreatic cancer (males), and kidney and colonic cancer (females) were also noted (p < 0.05).

Conclusions:

The study confirms a dose-dependent increase in squamous cell cancer incidence following PUVA therapy.
PUVA therapy is associated with increased risks for several other cancer types, warranting further investigation and careful patient selection.