Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic issues in pediatric pancreatitis.

Leena Kandula1, David C Whitcomb, Mark E Lowe

  • 1Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, 2nd Floor DeSoto Bldg., Pittsburgh, PA 15213, USA.

Current Gastroenterology Reports
|June 13, 2006
PubMed
Summary

Hospitalizations for pediatric pancreatitis are rising. Genetic mutations in trypsinogen, inhibitors, and cystic fibrosis transmembrane conductance regulator genes are linked to pancreatitis development and severity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.

Cell stem cell·2026
Same author

Pancreatitis Risk Genes Play a Major Role in Pediatric Pancreatitis: Insights From the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis.

Pancreas·2026
Same author

Complications of Pancreatitis-Knowledge Gaps and Research Opportunities: A Workshop Summary.

Pancreas·2026
Same author

Long-term disease progression in pediatric acute recurrent and chronic pancreatitis: A report from INSPPIRE.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2026
Same author

Utility and utilization of transabdominal ultrasound in pediatric patients with acute recurrent or chronic pancreatitis.

Journal of pediatric gastroenterology and nutrition·2025

Area of Science:

  • Pediatric Gastroenterology
  • Genetics
  • Molecular Biology

Background:

  • Pediatric pancreatitis, both acute and chronic, presents a growing hospitalization concern with significant morbidity.
  • Acute pancreatitis involves reversible pancreatic inflammation, while chronic pancreatitis causes irreversible structural and functional damage.

Purpose of the Study:

  • To explore the genetic underpinnings and pathophysiological mechanisms contributing to pediatric pancreatitis.
  • To understand the role of specific gene mutations in the development and severity of pancreatitis in children.

Main Methods:

  • Review of recent genetic findings related to pancreatitis.
  • Analysis of cell biology advancements impacting the understanding of pancreatic diseases.

Related Experiment Videos

Main Results:

  • Mutations in cationic trypsinogen are associated with hereditary pancreatitis.
  • Genetic variations in pancreatic secretory trypsin inhibitor and cystic fibrosis transmembrane conductance regulator genes play a role in pancreatitis.
  • Cytokine target gene mutations influence pancreatitis severity.

Conclusions:

  • Genetic factors are crucial in the etiology and progression of pediatric pancreatitis.
  • Advances in molecular biology and genetics enhance our comprehension of pancreatic disease pathophysiology.