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Individuals with schizophrenia present hypo- and hyperactivation during implicit cueing in an inhibitory task
Estibaliz Arce1, David S Leland, Daniel A Miller
1Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, CA 92093-0985, USA. esarce@uscd.edu
Neuroimage
|June 13, 2006
Summary
Individuals with schizophrenia show impaired cognitive control and cue processing, even with matched performance. Findings highlight parietal cortex involvement in inhibitory control and cue processing.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Schizophrenia is associated with cognitive deficits.
- Understanding neural mechanisms of cognitive control in schizophrenia is crucial.
Purpose of the Study:
- To investigate neural correlates of implicit cueing in schizophrenia.
- To compare individuals with schizophrenia (SZ) and healthy comparison subjects (HC) on an inhibitory task with matched performance accuracy.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used.
- 17 individuals with chronic schizophrenia and 17 healthy comparison subjects participated.
- A visual Go/Nogo task with implicit cueing was employed.
Main Results:
- Individuals with schizophrenia exhibited difficulties in inhibition and cue processing.
- Neural activity patterns differed between SZ and HC groups during the task.
Conclusions:
- Cognitive control and stimulus processing deficits in schizophrenia may underlie observed difficulties.
- The parietal cortex plays a significant role in cued inhibitory processes.
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