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Related Experiment Videos

Lichen planus and mesalazine.

E M Alstead1, A G Wilson, M J Farthing

  • 1Department of Gastroenterology, St. Bartholomew's Hospital, West Smithfield, London, England.

Journal of Clinical Gastroenterology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Lichen planus can be a complication of sulfasalazine and mesalazine. These aminosalicylate drugs may trigger lichen planus, which resolves upon drug withdrawal.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Sulfasalazine is a medication used to treat inflammatory conditions.
  • Lichen planus is an inflammatory condition affecting skin and mucous membranes.

Observation:

  • Two patients developed oral and cutaneous lichen planus while on sulfasalazine.
  • These patients experienced a recurrence of skin lesions when switched to mesalazine.

Findings:

  • Lichen planus resolved only after both sulfasalazine and mesalazine were discontinued.
  • The aminosalicylic acid component is implicated as the causative agent.

Implications:

  • Lichen planus should be considered a potential complication of mesalazine therapy.
  • Aminosalicylate drugs may pose a risk for developing lichen planus.