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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

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Related Experiment Video

Updated: Jun 30, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

Endoscopic Incisional Therapy for Benign Esophageal Strictures: A Systematic Review and Meta-Analysis.

Kobina Essilfie-Quaye1,2, Yizhong Wu3, Andrew Ofosu4

  • 1University of Central Florida College of Medicine, Orlando.

Journal of Clinical Gastroenterology
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Endoscopic incisional therapy (EIT) offers high technical success for benign esophageal strictures. While effective short-term, especially for naive and short strictures, long-term outcomes show recurrence and lower success in complex cases.

Keywords:
benign esophageal strictureselectrosurgical incisionendoscopic incisional therapymeta-analysissystematic review

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Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
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Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions

Published on: April 28, 2026

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Last Updated: Jun 30, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
04:08

Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions

Published on: April 28, 2026

Area of Science:

  • Gastroenterology
  • Minimally Invasive Surgery
  • Endoscopy

Background:

  • Benign esophageal strictures (BES) pose treatment challenges.
  • Endoscopic incisional therapy (EIT) is a minimally invasive option.
  • Long-term efficacy and safety of EIT for BES require evaluation.

Purpose of the Study:

  • To systematically review and meta-analyze outcomes of EIT for BES.
  • To assess technical success, clinical success rates, and adverse events.
  • To compare outcomes based on stricture characteristics (segment length, refractory status).

Main Methods:

  • Systematic literature search (PubMed, EMBASE, Cochrane, Google Scholar) following PRISMA 2020 guidelines.
  • Inclusion of studies reporting EIT outcomes in benign esophageal strictures.
  • Meta-analysis using random-effects model to pool technical success, clinical success at various time points, and subgroup analyses.

Main Results:

  • Fourteen studies with 396 patients were analyzed.
  • Pooled technical success rate was high at 98.5%.
  • Clinical success declined over time (88.1% at 1 month to 61.6% at 24 months).
  • Short-segment (92.5%) and naive (82.8%) strictures showed higher success than long-segment (16.4%) and refractory (43.9%) strictures.

Conclusions:

  • EIT is effective and safe for benign esophageal strictures, particularly short-segment and naive cases.
  • Excellent short-term results are observed.
  • Long-term outcomes are less consistent, with common recurrence, especially in long-segment and refractory strictures.