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Ontogeny of ingestive behavior.

Gerard P Smith1

  • 1Department of Psychiatry, Weill Medical College of Cornell University, Presbyterian Hospital, 21 Bloomingdale Road, White Plains, New York, New York 10605, USA. gpsmith@med.cornell.edu

Developmental Psychobiology
|June 14, 2006
PubMed
Summary

Early controls of meal size in rats emerge sequentially within the first three postnatal weeks. Metabolism and adiposity controls develop later, aiding research into childhood obesity and feeding behaviors.

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Area of Science:

  • Developmental biology
  • Neuroscience
  • Physiology

Background:

  • Understanding meal size control is crucial for addressing obesity.
  • Early life feeding behaviors influence long-term health.
  • Rodent models offer insights into human developmental processes.

Purpose of the Study:

  • To review the ontogeny of independent ingestion controls in rats.
  • To identify the developmental timeline of meal size regulation.
  • To explore the utility of independent ingestion in studying hyperphagia.

Main Methods:

  • Review of existing literature on rodent feeding behavior.
  • Analysis of developmental emergence of ingestion controls.
  • Examination of studies on monogenic obesity models in rats.

Main Results:

  • Direct and indirect controls of meal size appear sequentially in early postnatal development.
  • Metabolic and adiposity controls emerge later, post-weaning.
  • Independent ingestion effectively detects early hyperphagia in obesity models.

Conclusions:

  • Early life feeding controls are established sequentially, with metabolic factors developing later.
  • Independent ingestion is a valuable tool for studying developmental feeding disorders.
  • Findings have implications for translational research in human pediatric obesity.

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