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Related Experiment Videos

Intestinal neuronal dysplasia.

Richard Skába1, Miroslava Frantlová, Jaromir Horák

  • 1Department of Paediatric Surgery, 2nd Medical Faculty of the Charles University in Prague and Motol University Hospital, Prague, Czech Republic. richard.skaba@lfmotol.cuni.cz

European Journal of Gastroenterology & Hepatology
|June 15, 2006
PubMed
Summary

Intestinal neuronal dysplasia type B (IND B) is a disease of the submucous plexus with an unclear cause, possibly linked to fetal or postnatal intestinal issues. Diagnosis requires histological confirmation alongside clinical evaluation for this motility disorder.

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Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Histopathology

Background:

  • Intestinal neuronal dysplasia type B (IND B) is characterized by abnormalities in the submucous plexus.
  • The etiology of IND B is largely unknown, with a suspected congenital origin.
  • Associations with chronic intestinal obstruction suggest potential acquired causes.

Purpose of the Study:

  • To review the current understanding of Intestinal neuronal dysplasia type B.
  • To discuss the diagnostic challenges and treatment approaches for IND B.
  • To highlight the need for histological confirmation in diagnosing IND B.

Main Methods:

  • Review of existing literature on Intestinal neuronal dysplasia type B.
  • Analysis of clinical presentations and diagnostic criteria.

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  • Discussion of treatment strategies and outcomes.

    • Main Results:

    • The precise cause of IND B remains elusive.
    • IND B may arise from the enteric nervous system's response to obstruction or inflammation.
    • No consistent correlations have been found between clinical, radiological, or manometric findings and IND B.
    • Histological diagnosis is crucial for definitive identification.

    Conclusions:

    • A unified treatment concept for IND B is lacking.
    • Histological confirmation, coupled with clinical symptoms and patient follow-up, is essential for diagnosing IND B.
    • Further research is needed to elucidate the etiology and establish standardized treatments for this intestinal motility disorder.