Related Experiment Videos
[Modulation of immunocompetent cells in the synovial fluid TGF-beta]
J Kekow1, W L Gross, D A Carson
1Medizinische Abteilung der Rheumaklinik Bad Bramstedt.
Immunitat Und Infektion
|April 1, 1991
Abstract:
Mononuclear cells (MNC) in synovial fluids from patients with rheumatoid arthritis and other arthropathies differ clearly from MNC in peripheral blood. Typically the ratio of CD4(+)-/CD8+ lymphocytes is inverted and the response to mitogens/cytokines (IL-1/IL-2) is impaired. Active TGF-beta (transforming growth factor beta) was found to account for these abnormalities, and the major isoform was identified as TGF-beta 2.