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Stereoselective synthesis of the cytotoxic macrolide FD-891
Jorge García-Fortanet1, Juan Murga, Miguel Carda
1Departamento de Química Inorganica y Organica, Universitat Jaume I, Castellón, Spain.
Abstract:
[reaction: see text] A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Julia-Kocienski olefinations to connect the three fragments and a Yamaguchi reaction to close the macrolactone ring.
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