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Published on: April 28, 2019
Active viremia in rotavirus-infected mice
Sarah E Blutt1, Martijn Fenaux, Kelly L Warfield
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Journal of Virology
|June 16, 2006
Summary
Rotavirus commonly spreads beyond the gut in infected mice and children. Infectious rotavirus and its RNA were detected in blood, suggesting it can reach extraintestinal tissues.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Rotavirus is known to cause gastroenteritis in children and animals.
- Extraintestinal spread of rotavirus has been observed in animal models and humans.
Purpose of the Study:
- To investigate host or viral factors influencing rotavirus viremia.
- To determine the occurrence and characteristics of rotavirus antigenemia and viremia.
Main Methods:
- Infection of mice with homologous and heterologous rotaviruses.
- Monitoring for rotavirus antigenemia and viremia.
- Analysis of sera and plasma fractions for viral RNA and infectious virus.
Main Results:
- Rotavirus antigenemia and viremia were consistently observed in all infected mice.
- Age and mouse strain genetics did not affect the incidence of antigenemia or viremia.
- Rotavirus RNA and infectious virus were detected in the plasma fraction of blood.
Conclusions:
- Antigenemia and viremia are routine occurrences in rotavirus infections.
- Infectious rotavirus can access extraintestinal sites via the bloodstream.
