Related Experiment Video

Updated: Aug 7, 2026

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
10:01

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Published on: March 12, 2018

Door-to-balloon delays with percutaneous coronary intervention in ST-elevation myocardial infarction

Duane S Pinto1, Matthew Southard, Lauren Ciaglo

  • 1Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

American Heart Journal
|June 17, 2006
PubMed

Insights

Restoring blood flow quickly in ST-elevation myocardial infarction (STEMI) is crucial. Primary percutaneous coronary intervention (PCI) is superior if timely, but fibrinolysis is an option for delayed PCI, emphasizing rapid treatment for better outcomes.

Area of Science:

  • Cardiology
  • Emergency Medicine

Background:

  • Reperfusion therapy is critical for ST-elevation myocardial infarction (STEMI).
  • The benefits of reperfusion are time-dependent, regardless of the method used.
  • Timely restoration of blood flow minimizes myocardial damage and improves outcomes.

Purpose of the Study:

  • To compare the benefits and limitations of primary percutaneous coronary intervention (PCI) versus fibrinolysis for STEMI.
  • To emphasize the importance of rapid reperfusion therapy in STEMI management.

Main Methods:

  • Review of current literature comparing primary PCI and fibrinolysis for STEMI.
  • Analysis of time-dependent benefits and limitations of each reperfusion strategy.

Main Results:

  • Both primary PCI and fibrinolysis restore epicardial blood flow, but PCI offers more predictable success.
  • Fibrinolysis has limitations including unpredictable efficacy, reinfarction, and intracranial hemorrhage.
  • PCI is limited by implementation delays, especially for transfer patients.

Conclusions:

  • Primary PCI is the superior reperfusion strategy for STEMI when implemented rapidly by trained personnel.
  • Fibrinolysis should be considered when significant delays in primary PCI are anticipated.
  • Reducing time to reperfusion therapy for STEMI, whether PCI or fibrinolysis, is paramount.

More Related Videos

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...