Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bed rest and myopathies.

Arny A Ferrando1, Douglas Paddon-Jones, Robert R Wolfe

  • 1Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA. aferrand@utmb.edu

Current Opinion in Clinical Nutrition and Metabolic Care
|June 17, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Balanced Essential Amino Acids as Synergistic Therapeutic Agents in Resistance Training: Mechanistic and Clinical Perspectives on Muscle and Metabolic Health.

Nutrients·2026
Same author

Changes in Circulating MicroRNA Profiles During Arctic Military Training Target Inflammatory Pathways Independent of Macronutrient Intake.

The Journal of nutrition·2026
Same author

Whole-Body Protein Balance during Arctic Military Training Is Unaffected by Dietary Essential Amino Acid or Energy Density.

The Journal of nutrition·2026
Same author

A Factorial Model of the Minimum Metabolic Demand for Protein and Indispensable Amino Acids in Young Adult Males: Implications for Current Recommendations.

The Journal of nutrition·2026
Same author

Elevated miR-194-5p Expression during Short-Term Energy Deficit Attenuates Postexercise Muscle Protein Synthesis by Inhibiting Anabolic Signaling.

The Journal of nutrition·2026
Same author

Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study.

Journal of electrical bioimpedance·2025
Same journal

Seeing cachexia clearly: the evolution of body composition and radiological biomarkers in cancer wasting.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

The updated recommendations for medical nutrition in the perioperative period: a focus on early oral intake.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Pediatric and adolescent nutritional and metabolic assessment in the precision era.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Nutrition in cirrhosis: bridging guidelines and practice in hepatic disease.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Metabolic health in a changing world: widening the lens to climate, cities, and place.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Beyond the scale: a systems-level reframing of obesity and metabolic care.

Current opinion in clinical nutrition and metabolic care·2026
See all related articles

Skeletal muscle loss during critical illness is worsened by inactivity and stress. Essential amino acids can help prevent muscle wasting, especially in younger individuals, but more research is needed for chronic conditions and the elderly.

Area of Science:

  • Physiology
  • Metabolism
  • Geriatrics

Background:

  • Skeletal muscle serves as a crucial metabolic reserve.
  • Muscle loss can be significant with critical illness and injury.
  • Protein metabolism is altered during inactivity and physiological stress.

Purpose of the Study:

  • To review the importance of skeletal muscle as a metabolic reserve.
  • To discuss changes in protein metabolism during bed rest and stress.
  • To highlight interventions that can prevent skeletal muscle loss.

Main Methods:

  • Review of existing literature on skeletal muscle metabolism.
  • Analysis of protein metabolism changes during bed rest and physiological stress.
  • Evaluation of nutritional and hormonal interventions.

Related Experiment Videos

Main Results:

  • Nutritional supplementation with essential amino acids can prevent muscle loss from inactivity alone.
  • Bed rest combined with hypercortisolemia causes three times more muscle loss than bed rest alone.
  • Essential amino acids stimulate muscle anabolism during acute hypercortisolemia, but chronic effects require further study.

Conclusions:

  • Skeletal muscle loss results from the combined effects of inactivity and stress (hypercortisolemia).
  • Younger individuals show positive responses to interventions during bed rest.
  • Older individuals experience worse outcomes due to lower lean mass and the critical role of muscle as a metabolic reserve.